Tuya Pal, MD
Young black women with breast cancer are much less likely to have BRCA
testing or, if they carry a BRCA
mutation, to undergo risk-reducing prophylactic mastectomy or salpingo-oophorectomy, according to findings of a population-based study reported at the 2016 ASCO Annual Meeting.
The research identified disparities in receipt of BRCA
testing between non-Hispanic white women, Hispanic, and black women, with the latter being the least likely to have the testing. Likewise, black women who were BRCA
carriers were less likely to undergo risk-management practices compared with their white and Hispanic counterparts.
“We need to understand the reasons for these findings,” said lead study author Tuya Pal, MD, a clinical geneticist at the Moffitt Cancer Center in Tampa, Florida. Ultimately, it’s the patient who must decide whether to have genetic testing and take prophylactic measures for risk management, Pal said.
A number of factors may impact this decision, including cultural and economic circumstances, lack of information, and especially provider recommendations, which, Pal said, previous studies have indicated are very influential.
mutation carriers have a high (60%-70%) lifetime risk of breast cancer, at least a 50% risk of developing a second breast cancer, and up to a 44% risk of ovarian cancer, Pal noted in presenting the study’s findings during an ASCO press conference.
Using the Florida State Cancer Registry, researchers recruited women aged 50 or younger diagnosed with invasive breast cancer between the years 2009 and 2012 (N = 1621), and they were asked to complete a baseline survey. Of the total cross-sectional study cohort, 440 women were black, 284 were Hispanic, and 897 were white.
Overall, 917 participants reported having BRCA
testing, with similar uptake of testing among Hispanic and white women (62% and 65%, respectively), but only 36% of black women had the genetic test (P
= .025). “Even after controlling for meeting high-risk criteria based on national practice guidelines, economic status-related variables, and provider referral, we still had significant differences between black women and Hispanic and white women,” Pal said.
Among the subset of BRCA
mutation carriers (n = 92), the researchers found differences in uptake of risk-reducing bilateral mastectomy (RRM) and risk-reducing prophylactic salpingo-oophorectomy (RRSO) among the three groups. Sixty-eight percent of black women had RRM, compared with 85% of Hispanic women and 94% of whites.
Pal added that because mastectomy is not the only form of breast cancer risk management, investigators also looked at the proportion of women who had screening for breast cancer via MRI: 96% of the black women with the BRCA
mutation were screened, compared with 98% of their white counterparts and 100% of Hispanic carriers.
In the area of RRSO, Pal reported that 32% of black women had the procedure, versus 85% of Hispanics and 71% of white participants (P
= .02). Again, even after controlling for age, time since diagnosis, income, family history, and insurance status, she said, “we still had statistically significant results between Hispanic and white women compared with black women, where the rates were lower.”