Childhood Cancer Survivors at Risk for Heart Disease and Stroke

LISA SCHULMEISTER, MN, RN, FAAN
Monday, February 26, 2018
Adults who have survived childhood cancers have a higher risk of other health complications later on in life, including heart disease and stroke. A team of researchers led by Eric Chow, MD from Seattle Children’s Hospital analyzed data from the Childhood Cancer Survivor Study (CCSS) of 13,060 children who were observed through age 50 for the development of ischemic heart disease and stroke. Their 4,023 siblings were used to establish the baseline population risk in order to predict the risk of ischemic heart disease and stroke in 5-year survivors of childhood cancer.

Ischemic heart disease occurred in 265 childhood cancer survivors in the CCSS database and 295 CCSS experienced a stroke. Risk scores were based on a prediction model that included gender, type of chemotherapy, and radiotherapy exposure to the head, neck, or chest. Risk scores were categorized as low-, moderate-, and high-risk. The cumulative incidences of heart disease or stroke at age 50 among CCSS low-risk groups were < 5%, compared with approximately 20% for high-risk groups. The cumulative incidence was only 1% for siblings. The researchers concluded that this model may be useful to predict heart disease and stroke among childhood cancer survivors with reasonable accuracy.

Study findings are available at http://ascopubs.org/doi/abs/10.1200/JCO.2017.74.8673.

 

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Lisa Schulmeister, MN, RN, ACNS-BC, FAAN
 
Blog Info
Lisa Schulmeister, MN, RN, ACNS-BC, FAAN is an oncology nursing consultant and editor-in-chief of Oncology Nursing News.
Author Bio
Lisa Schulmeister, MN, RN, ACNS-BC, FAAN, is the Editor-in-Chief for OncLive Nursing. She is an oncology nursing consultant and adjunct assistant professor of nursing at Louisiana State Health Sciences Center in New Orleans, LA. She provides continuing nursing education to nurses across the Unites States, is active in several professional nursing organizations, and is intrigued by the many ways nurses use technology to communicate.
 
 
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