Monday, September 21, 2015
Dyspareunia is common among breast cancer survivors. It’s thought to be caused by low estrogen levels that dry out vaginal and labial tissue and result in pain upon penetration. To address this problem, researchers at Oregon Health & Science University in Portland explored the effectiveness of a topical analgesic liquid.
In the randomized, controlled, double-blind trial, estrogen-deficient breast cancer survivors with severe penetrative dyspareunia applied either saline or a 4% aqueous lidocaine topical solution to the vulvar vestibule for 3 minutes before vaginal penetration. After a 1-month blinded trial of patient-assessed twice-per-week tampon insertion or intercourse, all women received lidocaine for 2 months in an open-label trial. The primary outcome was patient-related assessment of penetration pain on a 0 to 10 scale. Secondary outcomes were sexual distress (measured using the Female Sexual Distress Scale), sexual function (measured using the Sexual Function Questionnaire), and resumption of intercourse.
The 46 women, who were screened to exclude those with pelvic muscle and organ pain, uniformly had clinical evidence of severe vulvovaginal atrophy, dyspareunia (median pain score 8 on 10-point scale), increased sexual distress scores (median 30.5; distress is present if score is >11), and abnormal sexual function.
Women who used lidocaine reported less pain during intercourse in the blinded phase (median score of 1.0 compared with saline score of 5.3). After open-label lidocaine use, 37 (90%) of 41 reported comfortable penetration. Sexual distress decreased significantly (median score, 14), and sexual function improved in all but one domain. Of 20 prior abstainers from intercourse who completed the study, 17 (85%) had resumed comfortable penetrative intimacy. No partners reported penile numbness.
The researchers concluded that breast cancer survivors with menopausal dyspareunia can have comfortable intercourse after applying liquid lidocaine to the vulvar vestibule before penetration. This is an easy, cost-effective measure that may enhance sexual intimacy for these women.
Goetsch MF, Lim JY, & Caughey AB. A practical solution for dyspareunia in breast cancer survivors: a randomized controlled trial. Journal of Clinical Oncology 2015; Published online before print July 27, 2015, doi: 10.1200/JCO.2014.60.7366

Talk about this article with nurses and others in the oncology community in the General Discussions Oncology Nursing News discussion group.
Lisa Schulmeister, MN, RN, ACNS-BC, FAAN
Blog Info
Lisa Schulmeister, MN, RN, ACNS-BC, FAAN is an oncology nursing consultant and editor-in-chief of Oncology Nursing News.
Author Bio
Lisa Schulmeister, MN, RN, ACNS-BC, FAAN, is the Editor-in-Chief for OncLive Nursing. She is an oncology nursing consultant and adjunct assistant professor of nursing at Louisiana State Health Sciences Center in New Orleans, LA. She provides continuing nursing education to nurses across the Unites States, is active in several professional nursing organizations, and is intrigued by the many ways nurses use technology to communicate.
External Resources

MJH Associates
American Journal of Managed Care
MD Magazine
Pharmacy Times
Physicians' Education Resource
Specialty Pharmacy Times
OncNurse Resources

Continuing Education
Web Exclusives

About Us
Advisory Board
Contact Us
Privacy Policy
Terms & Conditions
Intellisphere, LLC
2 Clarke Drive
Suite 100
Cranbury, NJ 08512
P: 609-716-7777
F: 609-716-4747

Copyright OncNursing 2006-2018
Intellisphere, LLC. All Rights Reserved.