Beth Sandy discusses the use of anti-psychotoci agent, olanzapine, when managing chemotherapy-induced nausea and vomiting (CINV).
Beth Sandy, CRNP, a nurse practitioner at the Abramson Cancer Center, Penn Medicine, discusses the use of the antipsychotic drug, olanzapine, as a treatment for chemotherapy-induced nausea and vomiting (CINV).
There have been recent advancements in other treatments for CINV, including work with NK1 and 5HT3 receptor antagonists. Recently, olanzapine has made it onto the NCCN guidelines for management of CINV. Despite the worry of sedation, this agent can be used as a preventive agent, and as needed. There are upcoming trials on the use of olanzapine in a triple regimen, in combination with the NK1 and 5HT3 receptor antagonists.