Dawn L. Hershman on Factors Contributing to CIPN


Dawn L. Hershman, MD, MS, Columbia University Medical Center, discusses the results of a recent study that found diabetes, age, and certain treatment regimens are contributing factors to developing chemotherapy-induced peripheral neuropathy (CIPN).

The study, which examined more than 1400 patients over the age of 65, reports that CIPN rates increase with age, and patients with diabetes treated with a taxane had nearly a twofold risk of developing CIPN, as were those treated with paclitaxel versus docetaxel.

Conversely, patients who had an autoimmune disease actually showed lower rates of CIPN, which, Hershman notes, raises intriguing questions for further study.

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