Men with a History of Testicular Cancer

Risk of developing high-risk prostate cancer higher than control group.

Researchers from the University of Maryland in Baltimore conducted a case-control study to assess the association of a history of testicular cancer with later development of intermediate- to high-risk prostate cancer. Earlier studies suggested that the incidence of prostate cancer is higher among men with a history of testicular cancer (12.6%) than among men who did not have a history of testicular cancer (2.8%). Men who had testicular cancer also were more likely to develop intermediate- or high-risk prostate cancers.

The researchers analyzed Surveillance, Epidemiology, and End Results (SEER) data on 32,435 men with a history of testicular cancer and 147,044 men with a history of melanoma. Melanoma was used as the control group because there is no known association between melanoma and prostate cancer; therefore, patients with melanoma would have a similar risk for developing prostate cancer as men in the general population.

The incidence of intermediate- or high-risk prostate cancer was 5.8% in the testicular cancer group and 1.1% in the control group. Testicular cancer was associated with a 4.7 times higher risk of developing all types of prostate cancer and a 5.2 times higher risk of developing intermediate- or high-risk disease. The findings suggest that surveillance for prostate cancer needs to be considered when creating survivorship care plans for testicular cancer survivors.

The study abstract can be found at