Genetics
Nivolumab/Ipilimumab Efficacy in Clear Cell RCC May Be Tied to Certain Immune-Cell Related Parameters
February 22, 2022
Article
Patients with 4-1BB or LAG-3–expressing T cells at baseline, or a high proportion of PD-L1–expressing myeloid cells and plasmacytoid dendritic cells during boost cycles, may be more likely to benefit from the combination of nivolumab and ipilimumab.
More Than A “Side Effect”: Why Pediatric Hearing Loss Is So Detrimental
February 11, 2022
Video
An expert discusses the consequences of cisplatin-induced hearing loss and ongoing research efforts to eliminate this associated risk for children receiving the treatment.
FDA Approves Asciminib for Treatment of 2 CML Subtypes
October 29, 2021
Article
The FDA have granted an accelerated approval to acimibinib, which treats CML by binding to the ABL myristoyl pocket.
Molecular Testing Guides Diagnosis, Treatment in Blood Cancers
October 19, 2020
Article
It is imperative that patients diagnosed with blood cancer undergo the proper molecular testing, one expert says.
Germline Testing for Lynch Syndrome: More Important Than Ever
October 04, 2020
Article
With the emergence of several targeted treatments that have shown efficacy in individuals with germline pathogenic variants, specifically in DNA mismatch repair, the need for germline genetic testing has become even more pronounced.
Gynecologic Cancer Genetics: Patient-Provider Communication Is Critical
September 13, 2020
Article
Nurses play a key role in ensuring that patients with gynecologic cancer understand the results and implications of genetic testing.
FDA Approves Guardant360 CDx Liquid Biopsy for Genomic Profiling for Solid Cancers
August 10, 2020
Article
The FDA has approved Guardant360® CDx for comprehensive genomic profiling in patients with any solid malignant cancer.
Cancer and Genetic Testing: Expert Answers Common Questions
August 02, 2020
Article
Genetic testing is more important now than ever before, as biomarker-driven cancer treatments continue to receive approval across many tumor types. While these personalized treatments are improving outcomes, navigating the landscape of genetic testing can leave patients with questions for their providers.
The Evolution of Genetics Among Hematologic Malignancies
June 17, 2020
Article
Given the recent use of genes to determine prognosis and treatment decisions in the field of hematology, it is important for providers to collaborate with geneticists.