Combinations May Combat PARP Resistance

Video

Combining PARP inhibitors with another kind of agent may be key in overcoming resistance.

The implementation of PARP inhibitors is one of the most exciting additions to the treatment of gynecologic cancer, said Leslie M. Randall, MD, MAS, associate professor in the Division of Gynecologic Oncology at the University of California in Irvine.

However, many patients become resistant to the drugs and progress. Combinations, such as a PARP inhibitor plus an immunotherapy agent or PI3K inhibitor, are now being explored to overcome this resistance and lead to better outcomes.

Recent Videos
Image of a woman with glasses wearing a striped blouse and a black sweater in front of an Oncology Nursing News branded backdrop
Screenshot of Kiah Purcell, MSN, AGPCNP-BC, in a video call with the frame surrounded by an Oncology Nursing News branded border
Photo of Jamie Carroll, APRN, CNP, MSN, from a video call with an Oncology Nursing News branded border around the frame
5 experts in this video
Image of Kayle Freeman, DNP, APRN, FNP-C, in a video call with an Oncology Nursing News border around the frame
Image of Jessie Desir, PhD, RN, AMB-BC, OCN, in a video call with a blue and gold Oncology Nursing News border surrounding the frame.
Related Content