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Opinion|Videos|January 31, 2024

Dosing JAK Inhibitors in Patients With Myelofibrosis

Author(s)Christine Cooper, RN, BSN, Aaron T. Gerds, MD, MS

For most JAK inhibitors dosing starts at the maximum safe dose, while ruxolitinib often requires lower initial doses and dose reductions over the first 12 weeks when cytopenias typically worsen before partially improving, warranting consideration of earlier switching to alternative JAK inhibitors instead of pushing through transfusions.

Episodes in this series

EP. 1 Diagnosing Myelofibrosis

EP. 1 Diagnosing Myelofibrosis

EP. 2 Assessing Risk Level of Patients With Myelofibrosis

EP. 2 Assessing Risk Level of Patients With Myelofibrosis

EP. 3 Educational Resources for Patients Diagnosed With Myelofibrosis

EP. 3 Educational Resources for Patients Diagnosed With Myelofibrosis

EP. 4 Key Patient Goals for Myelofibrosis Management

EP. 4 Key Patient Goals for Myelofibrosis Management

EP. 5 Management of Anemia in Patients With Myelofibrosis

EP. 5 Management of Anemia in Patients With Myelofibrosis

EP. 6 Clinical Data on the Approved JAK Inhibitors for Treatment of Myelofibrosis

EP. 6 Clinical Data on the Approved JAK Inhibitors for Treatment of Myelofibrosis

EP. 7 Adverse Events Seen With JAK Inhibitors for Myelofibrosis

EP. 7 Adverse Events Seen With JAK Inhibitors for Myelofibrosis

EP. 8 Assessing Treatment Response in Patients With Myelofibrosis

EP. 8 Assessing Treatment Response in Patients With Myelofibrosis

EP. 9 Best Approaches to Switching Therapies for a Patient With Myelofibrosis

EP. 9 Best Approaches to Switching Therapies for a Patient With Myelofibrosis

EP. 10 Dosing JAK Inhibitors in Patients With Myelofibrosis

EP. 10 Dosing JAK Inhibitors in Patients With Myelofibrosis

EP. 11 Key Takeaways for Patients With Myelofibrosis

EP. 11 Key Takeaways for Patients With Myelofibrosis

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