SPINET Trial Could Alter Practice for Patients With Lung NETs


Somatostatin analog lanreotide (Somatuline Depot) is being considered for patients with lung neuroendocrine tumors (NETs) in a potentially practice-changing clinical trial.

Diane Reidy-Lagunes, MD

Diane Reidy-Lagunes, MD

Diane Reidy-Lagunes, MD

Since its FDA approval in 2014, the somatostatin analog lanreotide (Somatuline Depot) has been creating fresh options for select patients with gastroenteropancreatic neuroendocrine tumors (NETs), given the significant improvement in progression-free survival (PFS) demonstrated in this population.

Now, investigators are examining the potential that the agent could have in patients with lung NETs—an area that is greatly lacking in research—in a potentially practice-changing clinical trial that seeks to determine the role of the synthetic growth inhibitory hormone in patients with the rare tumor type. Thus far, no prospective trials specifically for patients with lung NETs have been reported, researchers have noted.1

“Neuroendocrine tumors can start anywhere in the body,” said Diane Reidy-Lagunes, MD. “The most common place is in the gastrointestinal [GI] tract, but they also strike very frequently in the lung. The truth is that we really haven’t paid much attention to lung NETs, and it really needs to be considered.”

Lagunes is the principal investigator on the SPINET trial—an international, phase III, randomized, double-blind study evaluating the efficacy and safety of lanreotide versus placebo in patients with well-differentiated, metastatic and/or unresectable, typical or atypical lung NETs (NCT02683941).

“We are trying to get a really good understanding of whether somatostatin analogs work for lung NETS and, if they do, for how long?” explained Lagunes, a medical oncologist at Memorial Sloan Kettering Cancer Center. “It is an important study that can help us better understand the disease and then [better] help our patients.”

Lagunes said patients with lung NETs are frequently treated as though they have small-cell lung cancer, another type of NET. “However, we know [the tumors] are completely different; they are different genetically and clinically,” she said. “Therefore, these patients should not be treated with platinum-based therapy up front and shouldn’t be treated with radiation.

“Our lung colleagues are [starting to] understand that now as well, but we just don’t have the data and the clinical trials in lung NETs to prove that they should be treated similar to GI nets,” Lagunes said. “These patients are not necessarily treated by neuroendocrine specialists; they’ve been treated by world-renowned lung cancer specialists—but they are 2 different diseases. That’s part of the problem.”

The SPINET trial has 2 phases: a double-blind phase during which patients are randomized 2:1 to receive lanreotide autogel/depot versus placebo and an open-label period during which patients who already have received lanreotide would continue therapy while those in the placebo arm would have the option to cross over to lanreotide.

The primary analysis will occur during the double-blind phase of the trial, which will end when 175 progression or death events have been reached. Both parts of the open-label phase will end 6 months following the date of data cut-off. The primary endpoint of SPINET is PFS, which will be measured by central review every 12 weeks using RECIST v1.1 criteria. Secondary endpoints include overall survival, time-to-treatment failure, disease control rate, change in quality of life, and objective response rate.

To be eligible for enrollment, patients with a typical carcinoid tumor must have a mitotic index of <2 mitoses/2 mm2 and patients with an atypical carcinoid must have <10 mitoses/2 mm2 and/or foci of necrosis. Tumors also must be somatostatin receptor—positive upon imaging.

Patients who need somatostatin analog therapy for symptom management and those who have received such treatment within 6 weeks of randomization will be excluded from the trial. Additionally, patients may not have undergone more than 1 course of chemotherapy for lung NETs at any time.

SPINET, which started in February 2016, is planned for an enrollment of 216 patients and is estimated to be completed by August 2019. Patients are accruing at 11 sites in the United States, with European sites scheduled to open, as well. Lagunes said that SPINET is “not a very large study,” but that it would be difficult to recruit patients because the tumor type is relatively rare.

“This is why we are encouraging all physicians that if they do see a [patient with] a lung NET, to strongly consider referring them to major cancer centers to be able to discuss this trial and see if it’s appropriate for the patient we are addressing.”


  • Reidy DL, Kulke MH, Wolin EM, et al. Safety and efficacy of lanreotide depot/autogel (LAN) in patients with lung NETs: the randomized, double-blind, placebo (PBO)-controlled phase III SPINET study. Poster presented at: 2016 ASCO Annual Meeting; June 3-7, 2016; Chicago, IL. Abstract TPS8580.

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