Novel Drug Targets Cancer Stem Cell Pathway in Metastatic CRC Trial
An ongoing phase III trial is evaluating the combination of napabucasin, a stemness inhibitor, and FOLFIRI chemotherapy in patients with metastatic colorectal cancer.
Napabucasin (BBI-608), the most advanced cancer stemness inhibitor in development, is being evaluated in combination with FOLFIRI chemotherapy in patients with previously treated metastatic colorectal cancer (mCRC) ub a karge phase III trial (NCT02753127) that aims to test a long-pursued theory about overcoming resistance to cytotoxic therapy.
Napabucasin is an orally administered small molecule that inhibits the phosphorylation of STAT3. Overactivated STAT3 may drive tumor development by helping to maintain the ability of cancer stem cells to renew and differentiate. Previous studies have shown positive results for napabucasin. In a phase Ib/II study, results confirmed that napabucasin can be safely combined with FOLFIRI, with or without bevacizumab, in patients with advanced CRC who have received an average of >2 prior lines of therapy. In a phase III study, napabucasin monotherapy improved overall survival (OS) versus placebo for patients with pretreated advanced CRC whose tumors tested positive for phosphorylated STAT3.
The international CanStem303C trial is seeking to randomize 1250 patients in a 1:1 ratio to twice-daily napabucasin (240 mg) plus FOLFIRI or to FOLFIRI alone. Bevacizumab can be added in both arms at the investigator’s discretion. The trial’s primary endpoint is an improvement in median OS. Secondary endpoints include OS in biomarker-positive patients, defined as positivity for expression of nuclear beta-catenin, another cancer stemness signaling protein, and/ or phosphorylated STAT3.
To date, the most common adverse event (AE) observed with napabucasin therapy has been diarrhea. “We recommend, in the protocol, very aggressive and preemptive management of diarrhea, so that when the patients start the drug, they have been supplied with antidiarrheal agents, and have been educated that they need to hydrate themselves,” explained lead investigator Axel Grothey, MD, a medical oncologist with Mayo Clinic in Rochester, Minnesota. The other main AE investigators expect to see is fatigue, which is linked to the diarrhea. Other AEs are mild and include nausea, anorexia, and loss of appetite, Grothey said, but there is little to no concern of major toxicity in terms of blood counts, fevers, or high risk of infections. “It gets confounded, of course, by the toxicity of the underlying chemotherapy, the FOLFIRI backbone. It’s something we’ll closely monitor.”
WHO IS ELIGIBLE
Patients with metastatic CRC and an ECOG status of 0 or 1 who have failed prior first-line combination therapy containing oxaliplatin and a fluoropyrimidine with or without bevacizumab are eligible for the trial. The trial is open to patients regardless of biomarker status. The CanStem303C trial is among nearly a dozen clinical trials testing napabucasin in a range of tumor types that drug developer Boston Biomedical, Inc, is sponsoring. Phase III studies are ongoing in gastric/gastroesophageal junction adenocarcinoma (NCT02178956), pancreatic cancer (NCT02993731), and non-squamous non—small cell lung cancer (NCT02826161).