Robert Andtbacka Discusses T-VEC Trials

Robert Andtbacka, MD, associate professor, Division of Surgical Oncology Department of Surgery, University of Utah School of Medicine, discusses past, present, and future trials investigating T-VEC in melanoma.

T-VEC was already approved as a monotherapy, but is currently in ongoing studies to be used as a combination therapy. A phase I study showed that the therapy did not increase toxicity when combined with ipilimumab, and response rate when combining the drugs was high. Another study combined pembrolizumab with T-VEC and also showed no added toxicity and a 56% response rate.

An upcoming phase III study will compare the results of pembrolizumab plus T-VEC with pembrolizumab plus an injectable suspension.