End-of-Life Conversations: ‘When They Open the Door, You Have to Go In’
Patricia Jakel, MN, RN, AOCN, emphasized that the bond oncology nurses have with patients with cancer necessitates honest and often difficult conversations.
FDA Approves Denosumab Biosimiliars for Prior Authorized Indications
Two denosumab biosimilars have been approved by the FDA for all previously approved uses for the reference drugs in cancers and osteoporosis.
Toxicity May Be Underreported in Phase 3 Oncology Trials
A recent study found that toxicity is routinely minimized in phase 3 oncology trials, especially those that are not industry sponsored.
Antihistamines Linked to Improved Survival in Urothelial Carcinoma Treated with Immunotherapy
Adding antihistamines to atezolizumab led to a 46% OS rate and a 23% PFS rate in metastatic urothelial carcinoma.
Panitumumab Combo Elicits Response in mCRC Subset
Panitumumab plus ipilimumab and nivolumab signaled complete or partial response in 18 patients with KRAS/NRAS/BRAF wild-type MSS mCRC at the 12-week mark.
Educating Patients on the Intersection of Cancer Subtypes and DEI
Jessie Desir, PhD, RN, AMB-BC, OCN, discussed the need for awareness about cancer subtypes and their prevalence in certain populations.
Mobile App May Be Feasible for Tracking Oral Cancer Medication Adherence
Although participants in the study had greater rates of nonadherence postintervention, those who reported nonadherence at baseline saw some increase in adherence.
Older Patients with Lenalidomide-Refractory MM May Face Treatment Gaps
Real-world data show that older adults with lenalidomide-refractory MM have poor survival outcomes after 1 to 3 lines of therapy.
Rusfertide Plus SOC Reaches Response End Point in Phlebotomy-Dependent PV
Clinical response rates were higher in patients with phlebotomy-dependent polycythemia vera who received rusfertide than in those who received placebo.
PYX-201 Receives FDA Fast Track Designation for Recurrent/Metastatic HNSCC
The FDA has granted PYX-201 fast track designation for treatment of recurrent or metastatic HNSCC after progression post-chemoimmunotherapy.
Keeping Up With Cancer Research to Provide Patients With Up-to-Date Care
Staying up to date with data from trials and information from organizations dedicated to cancer research is crucial for oncology nurses and APPs.
FDA Reviews Resubmitted BLA for Odronextamab in R/R Follicular Lymphoma
The FDA has accepted the resubmission of a BLA for odronextamab for the treatment of patients with relapsed/refractory follicular lymphoma.
Communication and Education: Improving Patient Outcomes With Bispecific T-Cell Engager Therapies
OS Benefit With T-DXd in Unresectable/Metastatic HER2+ Gastric/GEJ Adenocarcinoma
T-DXd delivered an OS benefit for patients with unresectable or metastatic HER2-positive gastric and GEJ adenocarcinoma following trastuzumab-based treatment.
Optimizing First-Line Therapy for BRAF-Mutant Colorectal Cancer
Oncology nurses and APPs play a key role in educating patients on BREAKWATER study findings and their impact on BRAF-mutant CRC treatment.
Frontline Camizestrant Combo Increases PFS In Breast Cancer Subtypes
Camizestrant with a CDK4/6 inhibitor was well tolerated and effective as first-line therapy for patients with ESR1-mutated, HR-positive/HER2-negative advanced breast cancer.
Helping Patients Understand Secondary Cancer Risk
Patients who receive certain cancer treatments are at greater risk of secondary malignancies and must be educated accordingly.
FDA Approves Tislelizumab Combo for Advanced ESCC
The FDA approved tislelizumab-jsgr (Tevimbra) with platinum chemotherapy as a first-line treatment for adults with PD-L1-positive, unresectable or metastatic esophageal squamous cell carcinoma.
Hidden Cancer Risks of LA Wildfires
Hazards of the LA wildfires necessitate awareness that first responders and those central to the fires may be at risk for developing cancer.
OH2 Shows Safety and Anticancer Response with HX008 for Advanced Sarcoma
Preliminary findings suggest that OH2 monotherapy is safe, with promising responses observed when combined with HX008 in locally advanced or metastatic sarcoma.
Neoadjuvant Pembrolizumab Gets FDA Priority Review in Resectable HNSCC
Nivolumab/Ipilimumab Recieves FDA sBLA for Unresectable/Metastatic CRC
The FDA is conducting a priority review of nivolumab plus ipilimumab for the first-line treatment of patients with unresectable or metastatic MSI-H/dMMR colorectal cancer.
Rucaparib Data Show Need for Further BRCA+ Ovarian Cancer Research
For patients with relapsed BRCA-mutated ovarian carcinoma, rucaparib produced a median OS of 19.4 months vs 25.4 months with chemotherapy in new findings.
Petosemtamab/Pembrolizumab Receives FDA Breakthrough Designation for PD-L1+ HNSCC
The FDA granted petosemtamab plus pembrolizumab breakthrough therapy status for PD-L1–positive recurrent/metastatic head and neck squamous cell carcinoma.
Cilta-Cel Associated With Higher HRQOL for Lenalidomide-Refractory MM
Median time to sustained worsening of symptoms was 23.7 months with cilta-cel, compared with 18.9 months with SOC.
SIGX1094 Receives FDA Fast Track Designation in Diffuse Gastric Cancer
The FDA granted SIGX1094 fast track status as a treatment option for diffuse gastric cancer.
Opinion: Oncology Nurses Can Ease the Burden of Time Toxicity in Cancer Care
Similar to financial toxicity, time toxicity can have a profound impact on a patient’s quality of life.
FDA Fast Track Designation Given to AUTX-703 in Relapsed/Refractory AML
AUTX-703, a novel, oral KAT2A/B degrader, has received fast track designation for use in relapsed/refractory AML.
NCCN Guidelines Update Includes HEPZATO KIT for Uveal Melanoma
Updates to the NCCN guidelines recommend HEPZATO KIT for use in hepatic-dominant uveal melanoma as a Category 2A treatment option.
FDA Grants Fast Track Designation to RZ-001 for HCC
The FDA has given RZ-001 fast track designation for HCC after demonstrating therapeutic activity in preclinical studies.
Nivolumab/Ipilimumab To Be New MSI-H/dMMR mCRC Standard of Care
T-DXd PFS Benefit Significant Across HR+, HER2-Low Breast Cancer Mutations
AI Tool May Predict Response, Resistance in Advanced RCC
Olanzapine May Reduce Nausea, Vomiting From Radiation