Medical Crossfire®: DLL3-Directed Therapies in Small Cell Lung Cancer — A Nursing-Centered Approach to a New Era of Care

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Episode Description

In this podcast, experts Alissa J. Cooper, MD; Kelly Goodwin, NP; Stephanie J. McDonald, MSN, FNP-BC, AOCNP; and Rebecca W. Repetti, NP, provide a nursing-centered approach to administering DLL3-targeting drugs and managing their unique toxicities.

Learning Objectives

Upon successful completion of this activity, you should be better prepared to:

• Explain the unique biology of DLL3 in SCLC and its rationale as a therapeutic target
• Describe clinical efficacy, safety profiles, and mechanisms of DLL3-targeted therapies
• Identify strategies to monitor, recognize, and manage specific AEs associated with DLL3 therapies
• Implement effective nursing interventions and patient education approaches for novel DLL3-targeted therapies in multicenter care settings

Acknowledgment of Educational Grant Support

This activity is supported by educational grants from Amgen, Inc. and Boehringer Ingelheim Pharmaceuticals, Inc.

Chair:

Alissa J. Cooper, MD

Instructor in Medicine, Harvard Medical School
Thoracic Medical Oncologist, Dana-Farber Cancer Institute
Boston, MA

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Gilead Sciences, Novartis, Regeneron; Grant/Research Funding (to institution): AbbVie, Amgen, Daiichi Sankyo, Merck, Monte Rosa, Roche

Faculty:

Kelly Goodwin, NP

Nurse Practitioner
Center for Thoracic Cancers
Massachusetts General Hospital
Boston, MA

Kelly Goodwin has no relevant financial relationships with ineligible companies.

Stephanie J. McDonald, MSN, FNP-BC, AOCNP

Nurse Practitioner, Thoracic Oncology Program
Dana-Farber Cancer Institute
Boston, MA

Stephanie J. McDonald has no relevant financial relationships with ineligible companies.

Rebecca W. Repetti, NP

Adult Nurse Practitioner
Memorial Sloan Kettering Cancer Center
New York, NY

Rebecca W. Repetti has no relevant financial relationships with ineligible companies.

Faculty, Staff, and Planners’ Disclosures

In accordance with ACCME Guidelines, PER^® has identified and resolved all conflict of interest for faculty, staff, and planners prior to the start of this activity by using a multistep process.

The staff of Physicians’ Education Resource^®, LLC have no relevant financial relationships with ineligible companies.

This podcast, including the narration, was developed by PER^® editorial staff based on an online activity developed with these faculty. The narration was voiced by a PER staff member or by an AI tool.

To learn more about this topic, including additional key nursing considerations, go to https://www.gotoper.com/mc26dll3directed-activity.

Release Date

June 17, 2026

Expiration Date

June 17, 2027

Off-Label Disclosure and Disclaimer

This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a healthcare professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER^® or any company that provided commercial support for this activity.