Atezolizumab Improves Survival in Extensive-Stage Small Cell Lung Cancer
September 28th 2018In combination with the standard front-line chemotherapy regimen of carboplatin and etoposide, the addition of atezolizumab (Tecentriq) significantly prolonged survival in patients with extensive-stage small cell lung cancer (ES-SCLC).
FDA Grants Priority Review to Pembrolizumab for PD-L1-High Subgroup of NSCLC
September 12th 2018The Food and Drug Administration (FDA) granted priority review to pembrolizumab (Keytruda) monotherapy for the first-line treatment of patients with locally advanced or metastatic nonsquamous or squamous non-small cell lung cancer (NSCLC) whose tumors express PD-L1 without EGFR or ALK genomic tumor aberrations.
FDA Grants Priority Review to Pembrolizumab for Advanced Merkel Cell Carcinoma
September 4th 2018The Food and Drug Administration (FDA) granted priority review to pembrolizumab (Keytruda) for the treatment of adults and children with recurrent locally advanced or metastatic Merkel cell carcinoma, a rare skin cancer.
Physicians With Personal Cancer Experience May Recommend Ovarian Cancer Screening Despite Guidelines
August 29th 2018A recent survey of physicians revealed that 17% of doctors with personal experience with cancer were more likely than those without to act against established guidelines to recommend that low-risk women receive ovarian cancer screening.
Pediatric Guidelines for CAR T-Cell Therapy Help Nurses Recognize AEs Earlier
August 23rd 2018A year after the first CAR T-cell therapy was approved to treat pediatric patients with relapsed and/or refractory CD19-positive acute lymphoblastic leukemia (ALL), researchers have issued guidelines to help healthcare professionals recognize and treat the associated adverse events (AEs) from this treatment.
Genetic Variants Influence Treatment, Surveillance of Children with Medulloblastoma
July 13th 2018Based on the identification of 6 gene variations that make carriers susceptible to developing medulloblastoma and possibly other cancers, researchers have proposed subgroup-based counseling and screening recommendations.
Heated Chemo During Resection Shows No Benefit in Advanced CRC
July 13th 2018The addition of heated chemotherapy delivered to the abdomen during surgery delivered no survival benefit to patients with peritoneal carcinomatosis, according to phase III study results presented at the 2018 ASCO Annual Meeting.
FDA Grants Priority Review to Frontline Pembrolizumab Combo in Metastatic NSCLC
July 2nd 2018The FDA granted a priority review to the anti-PD-1 agent pembrolizumab (Keytruda) in combination with chemotherapy as a first-line treatment for metastatic squamous non-small cell lung cancer (NSCLC), regardless of PD-L1 expression.
FDA Grants Priority Review to Glasdegib for Acute Myeloid Leukemia
June 28th 2018The FDA granted a priority review to a new drug application for glasdegib, an investigational oral smoothened inhibitor, for the treatment of adult patients with previously untreated acute myeloid leukemia in combination with low-dose cytarabine, a type of chemotherapy.
FDA Approves Neulasta Biosimilar to Reduce Post-Chemo Febrile Neutropenia in Some Cancers
June 5th 2018The FDA approved pegfilgrastim-jmdb (Fulphila) as the first biosimilar to pegfilgrastim (Neulasta), a drug designed to reduce the risk of febrile neutropenia in patients treated with chemotherapy in certain types of cancer, according to a press release issued by the FDA.