Mabel Ryder, MD, endocrinologist and medical oncologist, Mayo Clinic, discusses targeting the tumor microenvironment in thyroid cancer.Â 

Previously, most research thyroid cancer progression has been done on the cancer cell itself, Ryder says. In her research, Ryder looked at how cells in the microenvironment would affect thyroid cancer cells and promote progression.

Using mouse models, Ryder identified tumor-associated macrophages and found evidence that the cells promote thyroid cancer progression.Â 

Ryder says that tumor-associated macrophages represent a potential therapeutic target for advanced thyroid cancer, particularly in patients whose disease has been resistant to most molecular targeted therapies. Â 

Mabel Ryder, MD

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Mabel Ryder on Tumor-Associated Macrophages in Thyroid Cancer