FDA Fast Tracks ALE.P02 for CLDN1-Poisitive Solid Cancers
The FDA granted a fast track designation to ALE-P02 for patients with CLDN1-positive squamous solid tumors.
Rapid Taper Plays Role in Suspected Opioid Misuse in Patients With Cancer
Clinicians should consider a rapid taper approach for patients with cancer who exhibit repeated signs of opioid misuse, an expert said.
Subcutaneous Pembrolizumab Is Noninferior to IV Formulation in NSCLC
Subcutaneous pembrolizumab plus chemotherapy was noninferior to IV pembrolizumab plus chemotherapy in treatment-naïve non-small cell lung cancer.
Bendamustine-Obinutuzumab Combo May Improve CR Rates in MCL
Bendamustine plus obinutuzumab outperformed historical data of bendamustine plus rituximab for patients with treatment naïve mantle cell lymphoma.
Bispecific Antibodies Are ‘Not Your Typical Chemotherapy’ in Myeloma Treatment
While bispecific antibodies tend to be well-tolerated for patients with multiple myeloma, there are still adverse effects clinicians should discuss with their patients.
Sacituzumab Tirumotecan Shows Promise in Pretreated Gynecologic Cancer
Sacituzumab tirumotecan had antitumor activity in pretreated advanced endometrial and ovarian cancer, data showed.
Mirdametinib Boosts Outcomes, QOL in NF1-PN
Mirdametinib led to confirmed responses and meaningful pain and health-related quality of life improvements in both children and adults with neurofibromatosis type 1-associated PNs.
Belantamab Mafodotin Triplet Improves OS in Relapsed/Refractory Myeloma
FDA OKs Ninlotinib Tablets With No Mealtime Restrictions for CML
The FDA approved ninlotinib tablets that do not have mealtime restrictions for Ph-positive CML in chronic phase and CML that was previously treated.
FDA Grants Rare Pediatric Designation to Elraglusib for Ewing Sarcoma
The FDA granted elraglusib a rare pediatric disease designation for Ewing sarcoma based on findings from the 1/2 Actuate-1902 trial.
Real World CAR T and Bispecific Data May Differ from Trials in DLBCL
Real-world data showed differences in outcomes by race/ethnicity in elderly patients.
SBRT Is Feasible for Localized Prostate Cancer
Five-fraction SBRT was noninferior to radiotherapy in a phase 3 trial of patients with low- to intermediate-risk localized prostate cancer.
Caregivers, Clinicians Must Be Familiar With CRS Risk After CAR T-Cell Therapy
At a recent Community Case Forum, an expert discussed the risk of cytokine release syndrome after patients undergo CAR T-cell therapy.
BLA Filed for Dato-DXd for EGFR-Mutant Lung Cancer
The FDA received a biologics license application for datopotamab deruxtecan for previously treated EGFR-mutant non-small cell lung cancer.
Topical Drug Combos May Be Beneficial for CIPN
Topical treatments may help ease chemotherapy-induced peripheral neuropathy, but more research is needed.
Novel Drug Combo Is Promising for PD-L1-Resistant Solid Cancers
Adding E-602 to cemiplimab demonstrated anti-tumor effects in patients PD-L1–resistant solid cancers.
Anito-Cel Shows 95% OS Rate in Relapsed/Refractory Myeloma
Anitocabtagene autoleucel may be a promising CAR-T cell therapy option for patients with relapsed/refractory myeloma.
Cannabis Has Drug-Drug Interaction Risks With Certain Chemotherapies
With many patients utilizing medical cannabis, it is important for nurses to be aware of potential drug-drug interactions, an expert said.
Virus Therapy Gets Orphan Drug Designation for Glioma Treatment
The FDA granted an orphan drug designation to herpes simplex virus type 1 (HSV-1) oncolytic virus MB-108 for malignant glioma treatment.
Enhancing Early-Stage NSCLC Care: Streamlining Biomarker Testing and Multidisciplinary Coordination Through Quality Improvement Initiatives
Nurse navigators and APPs are key members of the multidisciplinary team who can lead and implement QI efforts to ensure timely and effective biomarker testing for patients with early-stage NSCLC.
FDA Approves Obecabtagene Autoleucel for Relapsed/Refractory B-Cell Precursor ALL
The FDA approved obecabtagene autoleucel (obe-cel; Aucatzyl) for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
Mitazalimab Plus mFOLFIRINOX Improves Survival in Pancreatic Cancer
Mitazalimab combined with mFOLFIRINOX led to responses and survival benefits in patients with metastatic pancreatic ductal adenocarcinoma.
How to Overcome 4 Common Barriers to Cancer Clinical Trial Access
An oncology nurse discusses 4 common barriers certain patient populations face when it comes to oncology clinical trials, and what clinicians can do to mitigate these disparities.
Extended Lymphadenectomy Does Not Boost Survival in Bladder Cancer
Extended lymphadenectomy did not improve DFS or OS, and led to a higher incidence of perioperative morbidity and mortality.
Minority Groups May Experience Post-Mastectomy Disparities
Surveyed individuals who identified as a racial or ethnic minority reported difficulties discussing cancer diagnosis and treatment.
FDA Delays Decision Date for Zenocutuzumab in Lung, Pancreatic Cancer
The FDA extended the Prescription Drug User Fee Act date for the biologics license application seeking approval of zenocutuzumab for NRG1-positive lung and pancreatic cancer.
Real-World Data Show Efficacy of Brexu-Cel, ICANS Concerns
Brexu-cel is effective in treating patients with relapsed/refractory B-cell acute lymphoblastic leukemia, real-world data shows.
Novel ADC Shows Promise in Platinum-Resistant Ovarian Cancer
The novel drug SHR-A1921 was safe and efficacious in patients with platinum-resistant ovarian cancer, according to phase 1 data.
Letter Warns Clinicians of Severe Infections With Pralsetinib for NSCLC
An ad-hoc analysis found a higher rate of severe and life-threatening infections in patients with RET-mutant lung cancer treated with pralsetinib.
Cilta-Cel May Outperform Standard Care for Relapsed, Refractory Myeloma
An indirect comparison found that cilta-cel may be better than standard of care for patients with lenalidomise-refractory relapsed/refractory myeloma.
Mosunetuzumab/Polatuzumab Vedotin Triples PFS in LBCL
Nurses Lead Toxicity Monitoring in Indolent Lymphoma Care
Osimertinib/Chemo Boosts Survival in Frontline EGFR+ NSCLC
Lutetium Lu 177 Dotatate Brings Partial Response in Metastatic BP-NETs