Dr. Chlebowski Explains How Losing 5 Pounds Can Improve TNBC Survival

Rowan Chlebowski, MD, PhD, Professor and Chief, Harbor-UCLA Medical Center, Department of Internal Medicine, Medical Oncology/Hematology Member, Jonsson Comprehensive Cancer Center, discusses how losing 5 pounds, as seen in the Women’s Intervention Nutrition Study (WINS), had a positive impact for breast cancer patients, especially whose disease was triple-negative.

Chlebowski says losing 5 pounds is associated with changes in glucose metabolism, diabetes, and inflammatory factors, all of which can drive tumor growth.

The study found that by following a nutritional program, estrogen receptor (ER)-negative patients had a reduction of risk of death by 36%, while ER- and progesterone receptor (PR)-negative patients had a 54% reduction of risk of death compared with the control group.br