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Opinion|Videos|February 19, 2025

Jason’s Journey with ALK+ Metatstatic NSCLC

This is an actor portrayal of a hypothetical patient profile developed for educational purposes based on characteristics of patients with ALK+ non-small cell lung cancer as seen in clinical practice. The hypothetical case was co-developed by staff Medical Writers with Cancer Network/ONN

Episodes in this series

EP. 1 Robert’s Journey With EGFR+ Metastatic NSCLC

EP. 1 Robert’s Journey With EGFR+ Metastatic NSCLC

EP. 2 Patient Guidance and Education of EGFR Inhibitor Therapies

EP. 2 Patient Guidance and Education of EGFR Inhibitor Therapies

EP. 3 Strategies to Managing Cardiotoxic AEs with Osimertinib

EP. 3 Strategies to Managing Cardiotoxic AEs with Osimertinib

EP. 4 Balancing Treatment Benefits and Toxicity: Managing Quality of Life in EGFR+ NSCLC Patients

EP. 4 Balancing Treatment Benefits and Toxicity: Managing Quality of Life in EGFR+ NSCLC Patients

EP. 5 Strategies of Dose Modifications of Osimertinib and Other EGFR Inhibitors

EP. 5 Strategies of Dose Modifications of Osimertinib and Other EGFR Inhibitors

EP. 6 Management of GI Toxicities in Osimertinib and other EGFR Inhibitors

EP. 6 Management of GI Toxicities in Osimertinib and other EGFR Inhibitors

EP. 7 Importance of Multidisciplinary Team in Managing AEs of EGFR Inhibitors

EP. 7 Importance of Multidisciplinary Team in Managing AEs of EGFR Inhibitors

EP. 8 Comparison of Safety Profiles of EGFR Inhibitors

EP. 8 Comparison of Safety Profiles of EGFR Inhibitors

EP. 9 Jason’s Journey with ALK+ Metatstatic NSCLC

EP. 9 Jason’s Journey with ALK+ Metatstatic NSCLC

EP. 10 Patient Education and Guidance on Lorlatinib and Other ALK Inhibitors

EP. 10 Patient Education and Guidance on Lorlatinib and Other ALK Inhibitors

EP. 11 Management of Neurotox AEs with Lorlatinib

EP. 11 Management of Neurotox AEs with Lorlatinib

EP. 12 Management of Hyperlipidemia and Weight Gain with Lorlatinib

EP. 12 Management of Hyperlipidemia and Weight Gain with Lorlatinib

EP. 13 Management of GI AEs with ALK Inhibitors

EP. 13 Management of GI AEs with ALK Inhibitors

EP. 14 Dose Modifications When Managing Side Effects with ALK Inhibitors

EP. 14 Dose Modifications When Managing Side Effects with ALK Inhibitors

EP. 15 Role of Multidisciplinary Strategies in care of ALK+ NSCLC Patients

EP. 15 Role of Multidisciplinary Strategies in care of ALK+ NSCLC Patients

EP. 16 Patient Factors in Treatment Selection of ALK Inhibitors

EP. 16 Patient Factors in Treatment Selection of ALK Inhibitors

Video content above is prompted by the following:

34-year-old professional rock climber with ALK+ Stage IV metastatic NSCLC, previously healthy with no smoking history.
Persistent lower back pain unresponsive to rest and PT, followed by increased fatigue led to initial doctor visit.
CT scan revealed a left lung mass with lymph node involvement and a small metastasis on the spine; molecular testing confirmed ALK-positive status.
Started on lorlatinib, with manageable GI issues and fatigue as side effects; patient is motivated to return to climbing.

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