News

The duo of lenalidomide (Revlimid) and rituximab (Rituxan) is a combination that is feasible, safe and active as initial and maintenance therapy for use in patients with mantle cell lymphoma, according to a new study.

Some younger women with breast cancer may soon have a new first-line treatment option. Ribociclib (Kisqali), has been granted a breakthrough therapy designation by the FDA for use in combination with tamoxifen or an aromatase inhibitor (AI) as frontline treatment for pre- or perimenopausal women with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer.

Seattle Genetics announced that a supplemental biologics license application for brentuximab vedotin (Adcetris) used in combination with Adriamycin, vinblastine, and dacarbazine as a frontline treatment for advanced classical Hodgkin lymphoma has been granted a priority review by the FDA.

Progenics Pharmaceuticals announced that the FDA has granted a priority review designation to a novel version of the radiopharmaceutical iobenguane I-131 (Azedra), for patients with malignant or recurrent pheochromocytoma or paraganglioma.

A new study shows that using the targeted agents lapatinib (Tykerb) and trastuzumab (Herceptin) together, combined with an aromatase inhibitor (AI), significantly reduced the risk of death or progression in women with HER2-positive/HR-positive metastatic breast cancer compared with each single targeted agent in combination with an AI.

Researchers investigate the cellular biology of aging and the effects of cancer treatment associated with accelerated aging.

The combination of olaparib (Lynparza) and durvalumab (Imfinzi) for pretreated patients with germline BRCA-mutated (gBRCAm), HER2-negative metastatic breast cancer shows great promise for future treatment.

The FDA has granted priority review to a supplemental new drug application (sNDA) for use of dabrafenib (Tafinlar) and trametinib (Mekinist) in combination as an adjuvant treatment for patients with BRAFV600E– or V600K–positive stage III melanoma following complete resection.

Non-alcoholic fatty liver disease (NAFLD) is a risk factor for cancer, according to a recent report about a 7.5-year Korean study.

The FDA has granted a priority review to a new drug application (NDA) for apalutamide (ARN-509) for the treatment of patients with nonmetastatic castration-resistant prostate cancer (CRPC). Apalutamide is an oral androgen receptor inhibitor.

Mothaffar Fahed Rimawi, MD, explains the importance of targeting treatments for patients with low levels of HER2 protein based on their genetic mutations, and the possible use of immunotherapy for these patients.

The FDA has approved the combination of pertuzumab (Perjeta), trastuzumab (Herceptin) and chemotherapy as an adjuvant treatment for patients with HER2-positive early breast cancer at high risk for recurrence.

Nivolumab (Opdivo) is now approved by the Food and Drug Administration (FDA) as an adjuvant treatment for patients with completely resected melanoma with lymph node involvement or metastatic disease.

Based on findings from the phase III BFORE trial, the FDA has approved Bosutinib as a first-line treatment for a chronic myeloid leukemia subtype.

The FDA approved abozantinib (Cabometyx) for use in previously untreated patients who have advanced renal cell carcinoma (RCC).

Using oral rivaroxaban (Xarelto) to treat patients with cancer reduced venous thromboembolism (VTE) recurrence in a select-d trial.

The FDA has granted a priority review to a supplemental new drug application (sNDA) for the use of osimertinib as a first-line treatment for patients with non-small cell lung cancer (NSCLC) whose tumors harbor EGFR mutations.

Patients with cancer who suffer severe distress are more likely to miss appointments during the course of their radiation therapy and be admitted to the hospital.

New trial results represent the first successful effort in more than 30 years to imrove outcomes of first-line treatment in patients with advanced Hodgkin lymphoma (HL).

The FDA has granted a priority review to a supplemental biologics license application (sBLA) for use of this combination as a frontline treatment for intermediate- and poor-risk patients with advanced renal cell carcinoma (RCC).

A novel approach to the treatment of patients with smoldering multiple myeloma (SMM) produced durable results in a phase II trial.

Results of a phase I trial presented showed that the agent BLU-285 (Avapritinib) agent was well tolerated among patients with an advanced or aggressive form of systemic mastocytosis (ASM), a rare blood disorder that originates in mast cells.

Results of a new study show that adding ribociclib (Kisqali) to standard endocrine therapy with temporary ovarian suppression significantly improved progression-free survival (PFS) when used as a first-line treatment for

A supplemental biologics license application (sBLA) for pembrolizumab (Keytruda) has been granted FDA priority review status for the treatment of adults and children with relapsed/refractory primary mediastinal large B-cell lymphoma (PMBCL).

The American Society of Clinical Oncology (ASCO) recently published a special article in the Journal of Clinical Oncology that idicated that even one alcoholic drink per day can increase cancer risk.

This PARP inhibitor therapy is more effective than chemotherapy in extending progression-free survival and reducing risk of death from BRCA-positive breast cancer.

Shortening the intervals between chemotherapy cycles or administering the drugs sequentially compared to current techniques reduces early-stage breast cancer recurrence and mortality, study shows.

PARP inhibitor Rucaparib may soon be available to a wider group of patients with ovarian cancer.