Understanding the Adverse Events of PARP Inhibitors

February 23, 2019
Bobbie J. Rimel, MD

There are some adverse events that are common to all PARP inhibitors, and others that are specific to each drug.

There are three adverse events (AEs) that are common to all the PARP inhibitors used to treat ovarian cancer: fatigue, anemia, and nausea, explained Bobbie J. Rimel, MD, an assistant professor of obstetrics and gynecology at Cedars-Sinai.

However, there are also AEs that tend to be more common for certain agents. For example, niraparib (Zejula) is more likely to cause high blood pressure; rucaparib (Rubraca) is more likely to affect kidney function; and olaparib (Lynparza) is more likely to cause gastrointestinal issues.