There are three adverse events (AEs) that are common to all the PARP inhibitors used to treat ovarian cancer: fatigue, anemia, and nausea, explained Bobbie J. Rimel, MD, an assistant professor of obstetrics and gynecology at Cedars-Sinai.

However, there are also AEs that tend to be more common for certain agents. For example, niraparib (Zejula) is more likely to cause high blood pressure; rucaparib (Rubraca) is more likely to affect kidney function; and olaparib (Lynparza) is more likely to cause gastrointestinal issues.

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There are some adverse events that are common to all PARP inhibitors, and others that are specific to each drug.

Bobbie J. Rimel, MD

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Understanding the Adverse Events of PARP Inhibitors