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Opinion|Videos|March 21, 2025

Managing Adverse Events With Trastuzumab Deruxtecan: Early Detection and ILD Monitoring Strategies

Author(s)David Zhen, MD, Nataliya Uboha, MD, Samuel Cytryn, MD

Experts discuss the most common adverse events associated with trastuzumab deruxtecan, how to effectively identify and manage them to minimize treatment interruptions, and how to monitor and address interstitial lung disease (ILD), a known potential adverse effect of trastuzumab deruxtecan.

Episodes in this series

EP. 1 Navigating Immune-Related Adverse Events With Nivolumab in Upper GI Cancer

EP. 1 Navigating Immune-Related Adverse Events With Nivolumab in Upper GI Cancer

EP. 2 Robert’s Journey With HER2- Upper GI Cancer

EP. 2 Robert’s Journey With HER2- Upper GI Cancer

EP. 3 Strategies for Managing FOLFOX Toxicity in Upper GI Cancer

EP. 3 Strategies for Managing FOLFOX Toxicity in Upper GI Cancer

EP. 4 Supporting Patients Through Treatment for Upper GI Cancer Care

EP. 4 Supporting Patients Through Treatment for Upper GI Cancer Care

EP. 5 Communicating Treatment Adverse Effects: Strategies for Managing Expectations During Treatment for Upper GI Cancer

EP. 5 Communicating Treatment Adverse Effects: Strategies for Managing Expectations During Treatment for Upper GI Cancer

EP. 6 Balancing Treatment Intensity and Quality of Life in Upper GI Cancer

EP. 6 Balancing Treatment Intensity and Quality of Life in Upper GI Cancer

EP. 7 Megan’s Journey With HER2+ Upper GI Cancer

EP. 7 Megan’s Journey With HER2+ Upper GI Cancer

EP. 8 Managing Adverse Events With Trastuzumab Deruxtecan: Early Detection and ILD Monitoring Strategies

EP. 8 Managing Adverse Events With Trastuzumab Deruxtecan: Early Detection and ILD Monitoring Strategies

EP. 9 Managing Symptoms and Quality of Life During HER2-Targeted Therapy for Upper GI Cancer

EP. 9 Managing Symptoms and Quality of Life During HER2-Targeted Therapy for Upper GI Cancer

EP. 10 Multidisciplinary Collaboration in Managing Treatment-Related AEs in Upper GI Cancer

EP. 10 Multidisciplinary Collaboration in Managing Treatment-Related AEs in Upper GI Cancer

EP. 11 Bridging Communication Gaps: Comprehensive Care for Upper GI Cancer Treatment

EP. 11 Bridging Communication Gaps: Comprehensive Care for Upper GI Cancer Treatment

Video content above is prompted by the following:

• What are the most common adverse events associated with trastuzumab deruxtecan, and how can they be effectively identified and managed to minimize treatment interruptions?
• How do you monitor and address ILD, a known potential adverse effect of trastuzumab deruxtecan?

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John H. Strickler, MD; Stacey A. Cohen, MD; Aparna Parikh, MD; Kanwal P.S. Raghav, MBBS, MD

$Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma$

Cases and Conversations™: Sorting Through the Expanding Treatment Options for Patients with Relapsed/Refractory Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

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