Preventing Oral Toxicities in Metastatic Triple-Negative Breast Cancer

This video was supported by Gilead Sciences, Inc., but editorially independently created by the Oncology Nursing News team.

NP Theresa Stukus and NP Nelli Zafman discuss proactive strategies for preventing and managing oral toxicities associated with antibody-drug conjugate (ADC) therapy in patients with metastatic triple-negative breast cancer (mTNBC). NP Zafman emphasizes that early implementation of oral care measures is essential to reduce the risk of stomatitis and oral mucositis, which can significantly affect nutritional intake, quality of life, and treatment adherence. The faculty review practical preventive approaches, including corticosteroid mouth rinses, nonalcoholic mouthwash, saline rinses, and the use of a soft toothbrush, while stressing the importance of initiating these interventions early in treatment. They also encourage prompt reporting of oral symptoms so supportive care can be implemented before toxicities become severe. Throughout the discussion, the speakers reinforce the critical role of oncology nurse practitioners in educating patients, promoting adherence to preventive oral care practices, and minimizing treatment interruptions through early recognition and management of oral adverse events in metastatic triple-negative breast cancer.